Stability of thymol self-emulsifying chitosan pellets for the potential treatment of intestinal mucosa

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Authors

MACKŮ Jan KUBOVÁ Kateřina ČUBOVÁ URBANOVÁ Martina BRUS Jiří MUSELÍK Jan HLAVATÁ Daniela PAVELKOVÁ Miroslava PAVLOKOVÁ Sylvie VYSLOUŽIL Jakub VETCHÝ David

Year of publication 2023
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Pharmacy

Citation
Description The aim of the presented experimental study was to determine the stability of the Eugragit®L-coated chitosan/ Neusilin®US2 pellets containing thymol SEDDS. The first results confirmed the stability of uncoated self-emulsifying pellets with thymol in a half-year stability study in both storage conditions. On the contrary, the enteric-coated pellet formulation was stable only in the condition 25 °C/ 60 RH. Moreover, a mild deterioration of dissolution characteristics was reported.
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