Synthesis, activity and interaction of nitrone functionalized PAH derivatives
| Autoři | |
|---|---|
| Rok publikování | 2013 |
| Druh | Vyžádané přednášky |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | Polycyclic aromatic hydrocarbons (PAHs) are widely studied. Their carcinogenic properties are well known. In a sharp contrast to those effects the functionalized PAHs were recently identified as important candidates for cancer therapy.1 Mechanism of action is often simplified and studied at the DNA level. A lot of discussion has been held about groups being introduced to the PAHs structure. Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. According to our experience in nitrone chemistry2 the synthetic design of new PAHs derivatives was achieved by a multicomponent reaction of compounds 1-3. |
| Související projekty: |