Synthesis, activity and interaction of nitrone functionalized PAH derivatives

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Publikace nespadá pod Filozofickou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.
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POTÁČEK Milan BUCHLOVIČ Marian KŘÍŽ Zdeněk HOFR Ctirad

Rok publikování 2013
Druh Vyžádané přednášky
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
Popis Polycyclic aromatic hydrocarbons (PAHs) are widely studied. Their carcinogenic properties are well known. In a sharp contrast to those effects the functionalized PAHs were recently identified as important candidates for cancer therapy.1 Mechanism of action is often simplified and studied at the DNA level. A lot of discussion has been held about groups being introduced to the PAHs structure. Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. According to our experience in nitrone chemistry2 the synthetic design of new PAHs derivatives was achieved by a multicomponent reaction of compounds 1-3.
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