QT Interval Analysis in Electrograms of Isolated Guinea Pig Hearts Treated with Haloperidol

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Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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VESELÝ Petr HALÁMEK Josef STRAČINA Tibor KREJČÍŘOVÁ Lenka NOVÁKOVÁ Marie

Rok publikování 2013
Druh Článek ve sborníku
Konference Computing in Cardiology 2013
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Fyziologie
Klíčová slova isolated heart; QT interval; guinea pig; haloperidol; sigma receptor
Popis The influence of antipsychotic drug haloperidol on repolarization defined by QTc interval was analyzed in electrograms of 8 isolated guinea pig hearts. Each experiment consisted of four phases: stabilization (S), first haloperidol administration (H1), washout (W), and second haloperidol administration (H2). QTc was computed according to three correction models: Bazett’s, Fridericia’s and dynamic model based on transfer function (TRF). Mean value and standard deviation of QTc were assigned from the interval of 2000 beats in the middle of all four experimental phases. The inaccuracy of QTc given as STD/mean over all phases and experiments was 0.016+/-0.013, 0.015+/-0.010 and 0.0039+/-0.0024 for Bazett, Fridericia and TRF, respectively. The QTc prolongation by haloperidol was confirmed by TRF model. Relative QTcT prolongation caused by haloperidol was (H2-W 0.0062+/-0.0054, P=0.07) and shortening (H1-W -0.0038+/-0.0037, P=0.07) caused by washout. The QTcB and QTcF changes were given more by RR changes than haloperidol influence. The dynamic, subject specific model of QT/RR coupling must be used in drugs analysis.
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