CD36- and GPR120-mediated Ca2+ Signaling in Human Taste Bud Cells Mediates Differential Responses to Fatty Acids and is Altered in Obese Mice

Varování

Publikace nespadá pod Filozofickou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	OZDENER Mehmet Hakan SUBRAMANIAM Selvakumar SUNDARESAN Sinju ŠERÝ Omar HASHIMOTO Toshihiro ASAKAWA Yoshinori BESNARD Philippe ABUMRAD Nada A. KHAN Naim Akhtar
Rok publikování	2014
Druh	Článek v odborném periodiku
Časopis / Zdroj	Gastroenterology
Fakulta / Pracoviště MU	Přírodovědecká fakulta
Citace
Doi	http://dx.doi.org/10.1053/j.gastro.2014.01.006
Obor	Fyziologie
Klíčová slova	Taste; human; Serotonin; Linoleic acid; GLP-1; Lipids
Popis	It is important to increase our understanding of gustatory detection of dietary fat and its contribution to fat preference. We studied the roles of the fat taste receptors CD36 and GPR120 and their interactions via Ca2+ signaling in fungiform taste bud cells (TBC). CD36 and GPR120 have non-overlapping roles in TBC signaling during oro-gustatory perception of dietary lipids; these are differentially regulated by obesity.
Související projekty:	Epidemiologie a genetika Alzheimerovy choroby