ISOQUINOLINE ALKALOIDS OF THE CZECH AND CHINESE CULTURE OF MACLEAYA MICROCARPA (MAXIM.) FEDDE

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Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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PĚNČÍKOVÁ Kristýna PEŠ Ondřej TÁBORSKÝ Petr ZHI-HONG Jiang TÁBORSKÁ Eva

Rok publikování 2013
Druh Článek v odborném periodiku
Časopis / Zdroj CHEMICKE LISTY
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://www.chemicke-listy.cz/docs/full/2013_s3_s420-s453.pdf
Obor Biochemie
Klíčová slova ISOQUINOLINE ALKALOIDS; MACLEAYA MICROCARPA
Přiložené soubory
Popis Macleaya microcarpa (Maxim.) Fedde belongs, together with M. cordata (Willd.) R. Br. and their interspecific hybrid Macleaya x kewensis Turill, to the genus Macleaya, family Papaveraceae. Quaternary benzophenanthridine alkaloids (QBAs) sanguinarine (SA), chelerythrine (CHE), chelirubine (CR), chelilutine (CL) and the rarely occurring macarpine (MA) are the most interesting bioactive substances. While the major benzophenanthridine alkaloids SA and CHE are available commercially and have been the subjects of numerous biological studies, minor QBAs remained unnoticed for a long time due to their limited availability. Not long ago, first biological studies described the effects of these alkaloids on cells and identified a number of interesting properties, which puts these alkaloids in the center of interest for further research. Minor QBAs display strong anti-proliferative and apoptotic activity in vitro. MA has been reported as promising fluorescent probe for cell nuclei labeling and visualization of various stages of the cell cycle in fluorescence microscopy and flow cytometry. In addition, polycyclic, planar structure of the quaternary form allows intercalation of these alkaloids into DNA.
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