Analysis of hepatic deiodinase 2 mRNA levels in natural fish lake populations exposed to different levels of putative thyroid disrupters

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Publikace nespadá pod Filozofickou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.
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JARQUE ORTIZ Sergio BOSCH Carme CASADO Marta GRIMALT Joan O. RALDUA Demetrio PINA Benjamin

Rok publikování 2014
Druh Článek v odborném periodiku
Časopis / Zdroj Environmental Pollution
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www http://www.sciencedirect.com/science/article/pii/S0269749114000165
Doi http://dx.doi.org/10.1016/j.envpol.2014.01.010
Obor Znečištění a kontrola vody
Klíčová slova Salmo trutta; Persistent organic pollutants; Airborne pollution; Aryl hydrocarbon Receptor qRT-PCR
Popis Hepatic mRNA levels of the dio2 gene (deiodinase 2), implicated in thyroid hormone homeostasis, were analyzed in trout from six remote lakes in the Pyrenees (Spain) and the Tatra Mountains (Slovakia). Highest levels corresponded to fish from the two coldest lakes in Pyrenees, whereas relatively low levels were found in the Tatra lakes. These values correlated with the presence of highly-brominated poly-brominated diphenyl ethers (PBDE) congeners in the muscle of the same animals, reflecting the distribution of these compounds across European mountain ranges. In contrast, cyp1a expression levels, diagnostic for the presence of dioxin-like pollutants, mirrored the distribution of semi-volatile organochlorine compounds, indicating the specificity of the two types of biological responses. Exposure to PDBEs is known to increase transcription of dio2 and other thyroid-related genes in laboratory experiments; we propose that our data reflects the same phenomenon in natural populations, driven by anthropogenic pollutants at the environmental concentrations. (C) 2014 Elsevier Ltd. All rights reserved.
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