Mybs in mouse hair follicle development
| Autoři | |
|---|---|
| Rok publikování | 2014 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Tissue and Cell |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://www.sciencedirect.com/science/journal/00408166 |
| Doi | http://dx.doi.org/10.1016/j.tice.2014.06.006 |
| Obor | Genetika a molekulární biologie |
| Klíčová slova | Mybs; hair follicles; development; stem cells |
| Popis | The Myb transcription factors are involved in essential cellular processes, such as cell proliferation, dif-ferentiation and cell death. Biological functions carried out by specific Myb proteins are distinct. Hairfollicles are ectodermal-derived organs with cycling character of the growth resulting from the pres-ence of somatic stem cells. In this study, we followed the expression of the Myb proteins in developinghair follicles and in the hair follicle stem cell niche by immunofluorescence staining. During hair follicledevelopment, B-Myb was present in a few cells located in the area of cell division; c-Myb was abun-dant postanally in dividing cells but also in keratinizing zone. In addition, c-Myb was also detected incells under the hair follicle bulge. These findings indicate possible involvement of c-Myb in regulation of activated stem cells leaving the niche. |
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