Identifying craniofacial features associated with prenatal exposure to androgens and testing their relationship with brain development

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Publikace nespadá pod Filozofickou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
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MAREČKOVÁ Klára CHAKRAVARTY Mallar M. LAWRENCE Claire LEONARD Gabriel PERUSSE Daniel PERRON Michel PIKE Bruce G. RICHER Louis VEILLETTE Suzanne PAUSOVÁ Zdenka PAUS Tomáš

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj Brain Structure and Function
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://link.springer.com/article/10.1007%2Fs00429-014-0852-3
Doi http://dx.doi.org/10.1007/s00429-014-0852-3
Obor Neurologie, neurochirurgie, neurovědy
Klíčová slova Adolescents; Brain; Face; MRI; Prenatal androgens; Twins
Popis We used magnetic resonance (MR) images obtained in same-sex and opposite-sex dizygotic twins (n = 119, 8 years of age) to study possible effects of prenatal androgens on craniofacial features. Using a principal component analysis of 19 craniofacial landmarks placed on the MR images, we identified a principal component capturing craniofacial features that distinguished females with a presumed differential exposure to prenatal androgens by virtue of having a male (vs. a female) co-twin (Cohen's d = 0.76). Subsequently, we tested the possibility that this craniofacial "signature" of prenatal exposure to androgens predicts brain size, a known sexually dimorphic trait. In an independent sample of female adolescents (singletons; n = 462), we found that the facial signature predicts up to 8 % of variance in brain size. These findings are consistent with the organizational effects of androgens on brain development and suggest that the facial signature derived in this study could complement other indirect measures of prenatal exposure to androgens. © 2014 Springer-Verlag Berlin Heidelberg.
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