Mouse Incisor Stem Cell Niche and Myb Transcription Factors

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Publikace nespadá pod Filozofickou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.
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ŠVANDOVÁ Eva VESELÁ Barbora ŠMARDA Jan HAMPL Aleš RADLANSKI R. J. MATALOVA E.

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj Anatomia Histologia Embryologia
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
Doi http://dx.doi.org/10.1111/ahe.12145
Obor Genetika a molekulární biologie
Klíčová slova C-MYB; B-MYB; SELF-RENEWAL; A-MYB; DIFFERENTIATION; EXPRESSION; TOOTH; PROLIFERATION; LOCALIZATION; PROGENITORS
Popis Dental hard tissues are formed particularly by odontoblasts (dentin) and ameloblasts (enamel). Whereas the reparation of dentin is often observed, enamel does not regenerate in most species. However, in mouse incisor, a population of somatic stem cells in the cervical loop is responsible for the incisor regeneration. Understanding of the specificities of these cells is therefore of an interest in basic research as well as regenerative therapies. The Myb transcription factors are involved in essential cellular processes. B-Myb is often linked to the stem cell phenotype, and c-Myb expression marks undifferentiated and proliferating cells such as the stem cells. In the presented study, temporo-spatial expression of B-Myb and c-Myb proteins was correlated with localisation of putative somatic stem cells in the mouse incisor cervical loop by immunohistochemistry. B-Myb expression was localised mostly in the zone of transitamplifying cells, and c-Myb was found in the inner enamel epithelium, the surrounding mesenchyme and in differentiated cells. Taken together, neither B-Myb nor c-Myb was exclusively present or abundant in the area of the incisor stem cell niche. Their distribution, however, supports recently reported novel functions of c-Myb in differentiation of hard tissue cells.
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