Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child

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Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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DEMLOVÁ Regina MELICHÁRKOVÁ Kristýna ŘEHÁK Zdeněk KŘEN Leoš OŠLEJŠKOVÁ Hana ŠTĚRBA Jaroslav

Rok publikování 2014
Druh Článek v odborném periodiku
Časopis / Zdroj Current Oncology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.3747/co.21.2147
Obor Onkologie a hematologie
Klíčová slova Biomarkers; Metronomic chemotherapy; Pediatric glioma; PET imaging; Vinblastine
Popis Background: Children with high-grade glioma still have a poor prognosis despite the use of multimodal therapy including surgery, radiotherapy, and chemotherapy. New therapeutic strategies and methods evaluating such therapies are needed. Observation: Here we describe a child with anaplastic oligodendroglioma of the spinal cord who was unable to tolerate standard chemoradiotherapy and who had still-vital residual tumour during therapy. A good response was obtained with low-dose metronomic treatment containing vinblastine. The treatment was guided according to gradual response assessed using various positron-emission tomography tracers. Conclusions: Metronomic treatment guided by positron-emission tomography could be a reasonable option in some high-risk pediatric tumours.
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