THE EFFECT OF GLUCOSE VARIABILITY ON THE EXPRESSION OF GENES INVOLVED IN HYPERGLYCAEMIA-INDUCED TISSUE DAMAGE
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| Rok publikování | 2015 |
| Druh | Konferenční abstrakty |
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| Popis | Large prospective studies provided evidence of the relationship between long-term diabetes compensation expressed as HbA1c and the risk of diabetic cardiovascular complications. However, HbA1c and diabetes duration explain only small portion of the complications risk. Patients with the same HbA1c differ in amplitudes and duration of glycaemic excursions (so called glucose variability [GV]). Limited number of animal and in vitro studies showed that oscillating glucose may have more deleterious effect on cells than hyperglycaemia itself. Therefore, the aim of our study was to evaluate the effect of GV on the expression of genes whose products are involved in the development and protection against tissue damage in diabetes. Specifically, we measured gene expression of glyoxalase 1 (GLO1), and other enzymes with antioxidant activity – hemoxygenase (HMOX), superoxide dismutase 2 (SOD2) and enzyme with putative glyoxalase activity DJ1 in vitro. |
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