Decreased expression levels of PIWIL1, PIWIL2, and PIWIL4 are associated with worse survival in renal cell carcinoma patients

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Publikace nespadá pod Filozofickou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
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ILIEV Robert STANÍK Michal FEDORKO Michal POPRACH Alexandr VYCHYTILOVÁ Petra SLABÁ Kateřina SVOBODA Marek FABIAN Pavel PACÍK Dalibor DOLEŽEL Jan SLABÝ Ondřej

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj ONCOTARGETS AND THERAPY
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://www.dovepress.com/decreased-expression-levels-of-piwil1-piwil2-and-piwil4-are-associated-peer-reviewed-fulltext-article-OTT
Doi http://dx.doi.org/10.2147/OTT.S91295
Obor Onkologie a hematologie
Klíčová slova kidney cancer; PIWIL; piRNA
Přiložené soubory
Popis Piwi-interacting RNAs (piRNAs) are a newly discovered class of small non-coding RNAs involved in silencing of transposable elements and in sequence-specific chromatin modifications. PIWI proteins (PIWIL) belong to the family of Argonaute genes/proteins, bind piRNAs and their functioning have been described mainly in germ-line cells and more recently also in stem cells and cancer cells. There are four PIWI proteins PIWIL1, PIWIL2, PIWIL3, and PIWIL4 discovered in human till now. Recent studies suggested that deregulated the expression of Piwi proteins and selected piRNAs is common to many types of cancers. We found significantly lower expression of PIWIL1 (P<0.0001) and piR-823 (P=0.0001) in tumor tissue in comparison to paired renal parenchyma. Further, we observed progressive decrease in PIWIL1 (P=0.0228), PIWIL2 (P=0.0015), and PIWIL4 (P=0.0028) expression levels together with increasing clinical stage. PIWIL2 (P=0.0073) and PIWIL4 (P=0.0001) expression progressively decreased also with increasing Fuhrman grade. Most importantly, low-expression levels of PIWIL1 (P=0.009), PIWIL2 (P<0.0001), and PIWIL4 (P=0.0065) were significantly associated with worse overall survival in renal cell carcinoma (RCC) patients. Our results suggest the involvement of PIWIL genes and piR-823 in RCC pathogenesis, and indicate PIWIL1, PIWIL2, and PIWIL4 as potential prognostic biomarkers in patients with RCC.
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