Synthesis and Characterization of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-Propoxybenzoates and Their Hydrochloride Salts

Varování

Publikace nespadá pod Filozofickou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.

Autoři	MARVANOVÁ Pavlína PADRTOVÁ Tereza PEKÁREK Tomáš BRUS Jiří CZERNEK Jiří MOKRÝ Petr HUMPA Otakar ORAVEC Michal JAMPILEK Josef
Rok publikování	2016
Druh	Článek v odborném periodiku
Časopis / Zdroj	Molecules
Fakulta / Pracoviště MU	Středoevropský technologický institut
Citace
www	http://www.mdpi.com/1420-3049/21/6/707/htm
Doi	http://dx.doi.org/10.3390/molecules21060707
Obor	Organická chemie
Klíčová slova	arylcarbonyloxyaminopropanols; phenylpiperazines; synthesis; CP/MASNMR spectroscopy; IR spectroscopy; principle components analysis
Popis	Five new 3-(4-arylpiperazin-1-yl)-2-hydroxypropyl 4-propoxybenzoates were designed and synthesized as potential dual antihypertensive agents. The compounds were prepared as free bases and subsequently transformed to hydrochloride salts. The position of protonation of nitrogen atoms in the piperazine ring of hydrochloride salts was determined by means of C-13-CP/MAS and N-15-CP/MAS NMR and IR spectroscopy. Using these solid-state analytical techniques, it was found that both nitrogen atoms were protonated when excess hydrogen chloride was used for preparation of salts. On the other hand, when the equimolar amount of hydrogen chloride was used, piperazine nitrogen substituted by aryl was protonated.
Související projekty:	CEITEC - open access