Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon?

Varování

Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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ANDROVICOVA R. HORACEK J. ŠTARK Tibor DRAGO F. MICALE Vincenzo

Rok publikování 2017
Druh Článek v odborném periodiku
Časopis / Zdroj PHARMACOLOGICAL RESEARCH
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1016/j.phrs.2016.11.021
Obor Farmakologie a lékárnická chemie
Klíčová slova Endocannabinoids; Delta(9)-THC; Cannabinoid CB1 receptor; Sexual behavior
Popis The endocannabinoid system (ECS), which is composed of the cannabinoid receptors types 1 and 2 (CB1 and CB2) for marijuana's psychoactive ingredient Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the endogenous ligands (AEA and 2-AG) and the enzymatic systems involved in their biosynthesis and degradation, recently emerged as important modulator of emotional and non-emotional behaviors. For centuries, in addition to its recreational actions, several contradictory claims regarding the effects of Cannabis use in sexual functioning and behavior (e.g. aphrodisiac vs anti-aphrodisiac) of both sexes have been accumulated. The identification of Delta(9)-THC and later on, the discovery of the ECS have opened a potential therapeutic target for sexual dysfunctions, given the partial efficacy of current pharmacological treatment. In agreement with the bidirectional modulation induced by cannabinoids on several behavioral responses, the endogenous cannabinoid AEA elicited biphasic effects on sexual behavior as well. The present article reviews current available knowledge on herbal, synthetic and endogenous cannabinoids with respect to the modulation of several aspects of sexuality in preclinical and human studies, highlighting their therapeutic potential. (C) 2016 Elsevier Ltd. All rights reserved.
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