Reanalysis of Chinese Treponema pallidum samples: all Chinese samples cluster with SS14-like group of syphilis-causing treponemes

• Autoři: STROUHAL Michal; OPPELT Jan; MIKALOVÁ Lenka; ARORA Natasha; NIESELT Kay; GONZÁLEZ-CANDELAS Fernando; ŠMAJS David
• Rok publikování: 2018
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: BMC Research Notes
• Fakulta / Pracoviště MU: Lékařská fakulta
• www: https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-017-3106-7
• Doi: http://dx.doi.org/10.1186/s13104-017-3106-7
• Klíčová slova: Genome sequencing; Phylogenetic analysis; Single nucleotide variant; SyphilisTreponema pallidum
• Popis: Treponema pallidum subsp. pallidum (TPA) is the causative agent of syphilis. Genetic analyses of TPA reference strains and human clinical isolates have revealed two genetically distinct groups of syphilis-causing treponemes, called Nichols-like and SS14-like groups. So far, no genetic intermediates, i.e. strains containing a mixed pattern of Nichols-like and SS14-like genomic sequences, have been identified. Recently, Sun et al. (Oncotarget 2016. https://doi.org/10.18632/oncotarget.10154) described a new “phylogenetic group” (called Lineage 2) among Chinese TPA strains. This lineage exhibited a “mosaic genomic structure” of Nichols-like and SS14-like lineages.

Související projekty

• Molekulárně buněčná biologie pro biomedicínu
• Studium genomů patogenních treponem na základě analýzy jednotlivých buněk