Principles of Diffusion Kurtosis Imaging and its Role in Early Diagnosis of Neurodegenerative Disorders
| Název česky | Princip Diffusion Kurtosis Imaging a jeho role v časné diagnostice neurodegenerativních onemocnění |
|---|---|
| Autoři | |
| Rok publikování | 2018 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Brain Research Bulletin |
| Fakulta / Pracoviště MU | |
| Citace | |
| Doi | http://dx.doi.org/10.1016/j.brainresbull.2018.01.015 |
| Klíčová slova | Diffusion kurtosis imaging; neuroimaging; neurodegenerative disorders; Parkinson’s disease; Alzheimer’s disease; Huntington’s disease |
| Popis | Pathology of neurodegenerative diseases can be correlated with intra-neuronal as well as extracellular changes which lead to neuronal degeneration. The central nervous system (CNS) is a complex structure comprising of many biological barriers. These microstructural barriers might be affected by a variety of pathological processes. Specifically, changes in the brain tissue’s microstructure affect the diffusion of water which can be assessed non-invasively by diffusion weighted (DW) magnetic resonance imaging (MRI) techniques. Hence, the purpose of this article is to summarize the ongoing clinical and preclinical research on Parkinson’s, Alzheimer’s and Huntington diseases, using DKI and to discuss the role of this technique as an early stage biomarker of neurodegenerative conditions. |
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