Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs
Autoři | |
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Rok publikování | 2019 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Cell Communication and Signaling |
Fakulta / Pracoviště MU | |
Citace | |
www | https://biosignaling.biomedcentral.com/articles/10.1186/s12964-019-0470-z |
Doi | http://dx.doi.org/10.1186/s12964-019-0470-z |
Klíčová slova | CK1; Dishevelled; DVL3; Kinase; Mass spectrometry; NEK2; Phosphorylation; TTBK2; Wnt |
Popis | Dishevelled (DVL) is an essential component of the Wnt signaling cascades. Function of DVL is controlled by phosphorylation but the molecular details are missing. DVL3 contains 131 serines and threonines whose phosphorylation generates complex barcodes underlying diverse DVL3 functions. |
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