Genotyping of Treponema pallidumin Cuba (2018-2019): Increased Circulation of Recombinant Genotype and No New Treponema pallidum Subspeciesendemicum Infection Among Syphilis Patients

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Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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NODA Angel A. RODRIGUEZ Islay ŠMAJS David

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj Sexually transmitted diseases
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://journals.lww.com/stdjournal/Fulltext/2020/10000/Genotyping_of_Treponema_pallidum_in_Cuba.12.aspx
Doi http://dx.doi.org/10.1097/OLQ.0000000000001217
Klíčová slova Treponema pallidumin; Cuba; Syphilis Patients
Popis Objectives This study aimed to determine the allelic profiles ofTreponema pallidumin patients confirmed with syphilis in Cuba (2018-2019) and to explore mutations leading to macrolide and tetracycline resistance. Methods Multilocus sequence typing and polymerase chain reaction ofrrnloci (23S and 16S rDNA), followed by Sanger sequencing, were used to define the allelic profile of TPA and resistance mutations, respectively. Results Allelic profile 1.3.1 and the recombinant profile were identified, with 15.7.3 having an increased frequency. We did not detect the presence of theT. pallidumsubspeciesendemicumamong syphilis patients, as in previous reports. A high frequency of macrolide-resistant strains and the absence of mutations potentially causing tetracycline resistance were found. Conclusions Understanding the current status of treponemal infection in Cuban patients provides insights into the syphilis epidemiology.
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