Structural Alterations in Deep Brain Structures in Type 1 Diabetes

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Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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FILIP Pavel CANNA Antonietta MOHEET Amir BEDNARIK Petr GROHN Heidi LI Xiufeng KUMAR Anjali F. OLAWSKY Evan EBERLY Lynn E. SEAQUIST Elizabeth R. MANGIA Silvia

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj DIABETES
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://diabetes.diabetesjournals.org/content/69/11/2458.full-text.pdf
Doi http://dx.doi.org/10.2337/db19-1100
Klíčová slova Deep Brain Structures; Type 1 Diabetes
Popis Even though well known in type 2 diabetes, the existence of brain changes in type 1 diabetes (T1D) and both their neuroanatomical and clinical features are less well characterized. To fill the void in the current understanding of this disease, we sought to determine the possible neural correlate in long-duration T1D at several levels, including macrostructural, microstructural cerebral damage, and blood flow alterations. In this cross-sectional study, we compared a cohort of 61 patients with T1D with an average disease duration of 21 years with 54 well-matched control subjects without diabetes in a multimodal MRI protocol providing macrostructural metrics (cortical thickness and structural volumes), microstructural measures (T1-weighted/T2-weighted [T1w/T2w] ratio as a marker of myelin content, inflammation, and edema), and cerebral blood flow. Patients with T1D had higher T1w/T2w ratios in the right parahippocampal gyrus, the executive part of both putamina, both thalami, and the cerebellum. These alterations were reflected in lower putaminal and thalamic volume bilaterally. No cerebral blood flow differences between groups were found in any of these structures, suggesting nonvascular etiologies of these changes. Our findings implicate a marked nonvascular disruption in T1D of several essential neural nodes engaged in both cognitive and motor processing.
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