Decreased Global Strains of LV in Asymptomatic Female Duchenne Muscular Dystrophy Gene Carriers Using CMR-FT

Varování

Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	MASÁROVÁ Lucia MOJICA-PISCIOTTI Mary Luz PANOVSKÝ Roman KINCL Vladimír PEŠL Martin OPATŘIL Lukáš MÁCHAL Jan NOVÁK Jan HOLEČEK Tomáš JUŘÍKOVÁ Lenka FEITOVÁ Věra
Rok publikování	2021
Druh	Článek v odborném periodiku
Časopis / Zdroj	JACC: Cardiovascular Imaging
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://www.sciencedirect.com/science/article/abs/pii/S1936878X20308895?via%3Dihub#!
Doi	http://dx.doi.org/10.1016/j.jcmg.2020.09.016
Klíčová slova	Asymptomatic Female Duchenne Muscular Dystrophy; CMR-FT
Přiložené soubory	Decreased_Global_Strains_of_LV_in_Asymptomatic_Female_Duchenne_Muscular_Dystrophy_Gene_Carriers_Using_CMR-FT.pdf
Popis	Duchenne muscular dystrophy (DMD) is the most common X-linked muscular dystrophy. Male patients can have DMD, whereas female patients can be asymptomatic carriers of DMD (aDMD-FC). They can develop cardiomyopathy in their fourth to fifth decade, probably due to myocardial fibrosis. Early detection of myocardial dysfunction is critical for their prognosis. Cardiac magnetic resonance feature tracking (CMR-FT) may serve this purpose. It allows myocardial deformation assessment through global longitudinal strain (GLS), global radial strain (GRS), and global circumferential strain (GCS). Our prospective study aimed to evaluate these left ventricular (LV) strains in aDMD-FCs compared with healthy control subjects using CMR-FT. All healthy control subjects were women recruited from the same age groups to provide comparable results. We believe this comparative approach has not yet been published.
Související projekty:	Diferenciální diagnostika a odhad prognózy interních nemocí 2 Hodnocení funkce levé komory s využitím metody feature tracking u nosiček genů pro Duchennovu muskulární dystrofii