Differential diagnosis of tremor syndromes using MRI relaxometry

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Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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FILIP Pavel VOJTÍŠEK Lubomír BALÁŽ Marek MANGIA Silvia MICHAELI Shalom ŠUMEC Rastislav BAREŠ Martin

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj Parkinsonism and Related Disorders
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S135380202030849X
Doi http://dx.doi.org/10.1016/j.parkreldis.2020.10.048
Klíčová slova Tremor; Parkinson's disease; Essential tremor; Adiabatic T1 rho and T2 rho mapping; T1 and T2 mapping
Popis Differential diagnosis of the most common tremor syndromes - essential tremor (ET) and Parkinson's disease (PD) is burdened with high error rate. However, diagnostic MRI biomarkers applicable in this clinically highly relevant scenario remain an unfulfilled objective. The presented study was designed in search for possible candidate MRI protocols relevant for differential diagnostic process in tremor syndromes.10 non-advanced tremor-dominant PD patients meeting diagnostic criteria for clinically established PD, 12 isolated ET patients and 16 healthy controls were enrolled into this study. The study focused on relaxation MRI protocols - T1, T2, adiabatic T1 rho and adiabatic T2 rho due to their relatively low post-processing requirements enabling implementation into routine clinical practice. Compared to ET, PD patients had significantly longer T2 relaxation times in striata with dominant findings in the putamen contralateral to the clinically more affected body side. This difference was driven by alterations in the PD group as confirmed in the complementary comparison with healthy controls. According to the receiver operating characteristic analysis, this region provided a reasonable sensitivity of 0.91 and specificity of 0.89 in the differential diagnosis of PD and ET. In PD patients, we further found prolonged T1 rho in the substantia nigra compared to ET and healthy controls, and shorter T2 and T2 rho in the cerebellum compared to healthy controls. T2 relaxation time in the putamen contralateral to the clinically more affected body side is a plausible candidate diagnostic marker for the differentiation of PD and ET.
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