International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia

Varování

Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	CONDOLUCI A. DI BERGAMO L. T. LANGERBEINS P. HOECHSTETTER M. A. HERLING C. D. DE PAOLI L. DELGADO J. RABE K. G. GENTILE M. DOUBEK Michael MAURO F. R. CHIODIN G. MATTSSON M. BAHLO J. CUTRONA G. KOTAŠKOVÁ Jana DEAMBROGI C. SMEDBY K. E. SPINA V. BRUSCAGGIN A. WU W. MOIA R. BIANCHI E. GERBER B. ZUCCA E. GILLESSEN S. GHIELMINI M. CAVALLI F. STUSSI G. HESS M. A. BAUMANN T. S. NERI A. FERRARINI M. ROSENQUIST R. FORCONI F. FOA R. POSPÍŠILOVÁ Šárka MORABITO F. STILGENBAUER S. DOHNER H. PARIKH S. A. WIERDA W. G. MONTSERRAT E. GAIDANO G. HALLEK M. ROSSI D.
Rok publikování	2020
Druh	Článek v odborném periodiku
Časopis / Zdroj	Blood
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://watermark.silverchair.com/bloodbld2019003453.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAA-wwggPoBgkqhkiG9w0BBwagggPZMIID1QIBADCCA84GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMXRXeaAY25mjozM5SAgEQgIIDnxhMmZAU5cNiFCUDj79Os54hBBpUZ00qooo
Doi	http://dx.doi.org/10.1182/blood.2019003453
Klíčová slova	chronic lymphocytic leukemia; prognostic score
Popis	Most patients with chronic lymphocytic leukemia (CLL) are diagnosed with early-stage disease and managed with active surveillance. The individual course of patients with early-stage CLL is heterogeneous, and their probability of needing treatment is hardly anticipated at diagnosis. We aimed at developing an international prognostic score to predict time to first treatment (TTFT) in patients with CLL with early, asymptomatic disease (International Prognostic Score for Early-stage CLL [IPS-E]). Individual patient data from 11 international cohorts of patients with early-stage CLL (n = 4933) were analyzed to build and validate the prognostic score. Three covariates were consistently and independently correlated with TTFT: unmutated immunoglobulin heavy variable gene (IGHV), absolute lymphocyte count higher than 15 x 10(9)/L, and presence of palpable lymph nodes. The IPS-E was the sum of the covariates (1 point each), and separated low-risk (score 0), intermediate-risk (score 1), and high-risk (score 2-3) patients showing a distinct TTFT. The score accuracy was validated in 9 cohorts staged by the Binet system and 1 cohort staged by the Rai system. The C-index was 0.74 in the training series and 0.70 in the aggregate of validation series. By meta-analysis of the training and validation cohorts, the 5-year cumulative risk for treatment start was 8.4%, 28.4%, and 61.2% among low-risk, intermediate-risk, and high-risk patients, respectively. The IPS-E is a simple and robust prognostic model that predicts the likelihood of treatment requirement in patients with early-stage CLL. The IPS-E can be useful in clinical management and in the design of early intervention clinical trials.
Související projekty:	CEITEC 2020 Comprehensive prognostic and predictive panel for chronic lymphocytic leukemia: a next-generation sequencing tool suitable for clinical practice and study of genetic architecture behind the disease progress