Progressive Tumefactive Demyelination as the Only Result of Extensive Diagnostic Work-Up: A Case Report

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Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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ŠTOURAČ Pavel KOLČAVA Jan KEŘKOVSKÝ Miloš KOPŘIVOVÁ Tereza KŘEN Leoš BEDNAŘÍK Josef

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Frontiers in Neurology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.frontiersin.org/articles/10.3389/fneur.2021.701663/full
Doi http://dx.doi.org/10.3389/fneur.2021.701663
Klíčová slova demyelinating diseases; multiple sclerosis; neuropathology; neuroradiology; case report
Popis Tumefactive demyelinating lesions belong to the rare variants of multiple sclerosis, posing a diagnostic challenge since it is difficult to distinguish them from a neoplasm or other brain lesions and they require a careful differential diagnosis. This contribution presents the case report of a young female with progressive tumefactive demyelinating brain and spinal cord lesions. An extensive diagnostic process including two brain biopsies and an autopsy did not reveal any explanatory diagnosis other than multiple sclerosis. The patient was treated by various disease-modifying treatments without significant effect and died from ascendent infection via ventriculoperitoneal shunt resulting in Staphylococcus aureus meningitis.
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