Serotonin limits generation of chromaffin cells during adrenal organ development

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Publikace nespadá pod Filozofickou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.
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KAMENEVA Polina MELNIKOVA Victoria I. KASTRITI Maria Eleni KURTOVA Anastasia KRYUKOV Emil MURTAZINA Aliia FAURE Louis POVERENNAYA Irina ARTEMOV Artem V. KALININA Tatiana S. KUDRYASHOV Nikita V. BADER Michael ŠKODA Jan CHLAPEK Petr CURYLOVÁ Lucie SOURADA Lukáš NERADIL Jakub TESAROVA Marketa PASQUALETTI Massimo GASPAR Patricia YAKUSHOV Vasily D. SHEFTEL Boris I. ZIKMUND Tomas KAISER Jozef FRIED Kaj ALENINA Natalia VORONEZHSKAYA Elena E. ADAMEYKO Igor

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj Nature Communications
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://www.nature.com/articles/s41467-022-30438-w
Doi http://dx.doi.org/10.1038/s41467-022-30438-w
Klíčová slova serotonin; HTR3A; adrenal gland; neuroblastoma
Popis Adrenal glands are the major organs releasing catecholamines and regulating our stress response. The mechanisms balancing generation of adrenergic chromaffin cells and protecting against neuroblastoma tumors are still enigmatic. Here we revealed that serotonin (5HT) controls the numbers of chromaffin cells by acting upon their immediate progenitor "bridge" cells via 5-hydroxytryptamine receptor 3A (HTR3A), and the aggressive HTR3A(high) human neuroblastoma cell lines reduce proliferation in response to HTR3A-specific agonists. In embryos (in vivo), the physiological increase of 5HT caused a prolongation of the cell cycle in "bridge" progenitors leading to a smaller chromaffin population and changing the balance of hormones and behavioral patterns in adulthood. These behavioral effects and smaller adrenals were mirrored in the progeny of pregnant female mice subjected to experimental stress, suggesting a maternal-fetal link that controls developmental adaptations. Finally, these results corresponded to a size-distribution of adrenals found in wild rodents with different coping strategies.
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