Cyanine-flavonol hybrids as NIR-light activatable carbon monoxide donors in methanol and aqueous solutions

• Autoři: YANG Qiuyun; MUCHOVA Lucie; ŠTACKOVÁ Lenka; ŠTACKO Peter; ŠINDELÁŘ Vladimír; VÍTEK Libor; KLÁN Petr
• Rok publikování: 2022
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Chemical Communications
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• www: https://pubs.rsc.org/en/content/articlelanding/2022/CC/D2CC02648A
• Doi: http://dx.doi.org/10.1039/d2cc02648a
• Klíčová slova: MECHANISMS; MOLECULES; ACID; DYES
• Popis: Here we report on carbon monoxide-photoreleasable compounds (photoCORMs) that combine heptamethine cyanine and flavonol chromophores and are activated upon irradiation with near-infrared light. Excellent CO-release yields and uncaging cross sections in aqueous solutions, enhanced water solubilities thanks to polar substituents or a host-guest approach using cucurbit[7]uril are demonstrated. The hybrids display outstanding biocompatibility and diverse, structure-dependent cell penetrability and internalization.

Související projekty

• CETOCOEN Excellence
• CETOCOEN Excellence
• RECETOX RI
• Flavonoidy jako unikátní třída molekul fotochemicky uvolňujících oxid uhelnatý