Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling

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Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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RAUDENSKÁ Martina BALVAN Jan HÁNĚLOVÁ Klára BUGAJOVÁ Mária MASAŘÍK Michal

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S0304419X23000896?via%3Dihub
Doi http://dx.doi.org/10.1016/j.bbcan.2023.188940
Klíčová slova Head and neck cancer; Cancer-associated fibroblasts; Cancer therapy; Tumor microenvironment; Resistance to therapy
Popis Cancer-associated fibroblasts (CAFs) are involved in critical aspects of head and neck squamous cell carcinoma (HNSCC) pathogenesis, such as the formation of a tumor-permissive extracellular matrix structure, angiogenesis, or immune and metabolic reprogramming of the tumor microenvironment (TME), with implications for metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effect of CAFs in TME is likely to reflect the heterogeneity and plasticity of their population, with context-dependent effects on carcinogenesis. The specific properties of CAFs provide many targetable molecules that could play an important role in the future therapy of HNSCC. In this review article, we will focus on the role of CAFs in the TME of HNSCC tumors. We will also discuss clinically relevant agents targeting CAFs, their signals, and signaling pathways, which are activated by CAFs in cancer cells, with the potential for repurposing for HNSCC therapy.
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