Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study

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Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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OBDRŽÁLKOVÁ Marie USTOHAL Libor HLAVACOVA Natasa MAYEROVÁ Michaela ČEŠKOVÁ Eva KAŠPÁREK Tomáš JEZOVA Daniela

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj Heliyon
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S2405844023083810?via%3Dihub
Doi http://dx.doi.org/10.1016/j.heliyon.2023.e21173
Klíčová slova Aldosterone; Cortisol; Non-affective psychosis
Popis The aim of this pilot study was to find whether the dysregulation of neuroendocrine biomarker signaling pathways in the first episode of non-affective psychosis is a predictive factor of treat-ment outcome. Patients with the first episode of non-affective psychosis (N = 29) were examined at admission, at discharge, and at follow-up (N = 23). The biomarkers included serum aldoste-rone, cortisol, free thyroxine, thyroid stimulating hormone, and prolactin. We revealed lower baseline aldosterone and higher baseline cortisol concentrations in patients with very good outcome compared to those with good outcome after one year. We failed to reveal any significant association between treatment outcome and neurohumoral biomarkers in the whole sample at 1-year follow-up. However, baseline aldosterone concentrations negatively correlated with total PANSS scores at the discharge. Lower baseline aldosterone and higher baseline cortisol concentrations have the potential to predict a more favorable outcome for patients with the first episode of psychosis.
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