Prodromal Diagnosis of Lewy Body Diseases Based on the Assessment of Graphomotor and Handwriting Difficulties

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Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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GALAZ Zoltan MEKYSKA Jiri MUCHA Jan ZVONCAK Vojtech SMEKAL Zdenek FAUNDEZ-ZANUY Marcos BRABENEC Luboš MORÁVKOVÁ Ivona REKTOROVÁ Irena

Rok publikování 2022
Druh Článek ve sborníku
Konference Intertwining Graphonomics with Human Movements
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
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Doi http://dx.doi.org/10.1007/978-3-031-19745-1_19
Klíčová slova Lewy body diseases; Online handwriting; Graphomotor difficulties; Handwriting difficulties; Machine learning; Prodromal diagnosis
Popis To this date, studies focusing on the prodromal diagnosis of Lewy body diseases (LBDs) based on quantitative analysis of graphomotor and handwriting difficulties are missing. In this work, we enrolled 18 subjects diagnosed with possible or probable mild cognitive impairment with Lewy bodies (MCI-LB), 7 subjects having more than 50% probability of developing Parkinson's disease (PD), 21 subjects with both possible/probable MCI-LB and probability of PD > 50%, and 37 age- and gender-matched healthy controls (HC). Each participant performed three tasks: Archimedean spiral drawing (to quantify graphomotor difficulties), sentence writing task (to quantify handwriting difficulties), and pentagon copying test (to quantify cognitive decline). Next, we parameterized the acquired data by various temporal, kinematic, dynamic, spatial, and task-specific features. And finally, we trained classification models for each task separately as well as a model for their combination to estimate the predictive power of the features for the identification of LBDs. Using this approach we were able to identify prodromal LBDs with 74% accuracy and showed the promising potential of computerized objective and non-invasive diagnosis of LBDs based on the assessment of graphomotor and handwriting difficulties.
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