Isolated Rat Aorta Model in Doxorubicin Toxicity Study - pilot data

• Název česky: Model izolované aorty ve studiu doxorubicinové toxicity
• Autoři: BARTÁKOVÁ Anna; STRAČINA Tibor; ŠŮSTKOVÁ Lucie; MARHEFKA Filip; RAFČÍKOVÁ Julie; LAŠKA Michal; NÁDENÍČEK Jaroslav; NOVÁKOVÁ Marie
• Rok publikování: 2024
• Druh: Konferenční abstrakty
• Fakulta / Pracoviště MU: Lékařská fakulta
• Popis: This pilot study aimed to investigate the effect of doxorubicin (DOX) on vascular reactivity using an isolated aorta model. Aorta rings from Wistar rats were incubated with Krebs-Henseleit solution with or without DOX, followed by tension measurement on a myograph. Responses to phenylephrine, acetylcholine, and nitric oxide synthase (NOS) inactivation were evaluated. The results revealed no significant differences between DOX and control groups in adrenergic and cholinergic responses or tension changes after NOS inactivation. These findings suggest that acute DOX exposure at 1 µM does not affect vascular reactivity in this model, warranting further investigation into the potential impact of chronic drug administration on vascular toxicity.

Související projekty

• Protektivní potenciál sigma ligandů a antihypertenziv u doxorubicinové kardiotoxicity: komplexní experimentální přístup
• Analýza (dys)funkce: od molekul k živému organismu