Advances in engineering substrate scope of Pseudomonas cell factories

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Publikace nespadá pod Filozofickou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.
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FERREIRA DA SILVA Miguel Joao DONATI Stefano DVOŘÁK Pavel

Rok publikování 2025
Druh Článek v odborném periodiku
Časopis / Zdroj Current Opinion in Biotechnology
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://doi.org/10.1016/j.copbio.2025.103270
Doi http://dx.doi.org/10.1016/j.copbio.2025.103270
Klíčová slova CO-UTILIZATION; D-XYLOSE; PUTIDA STRAINS; METABOLISM; GENOME; WASTE; BIODEGRADATION; CELLOBIOSE; PLASTICS; KT2440
Popis Most current industrial bioprocesses use well-established model microorganisms and simple sugar substrates from edible starch or molasses. To broaden and sustain bioprocesses, we need to explore new robust microbial hosts with desirable traits and ideally exploit diverse waste-derived substrates. Pseudomonas species are prime candidates for new generation of industrial biotechnology due to their resilient physiology and adaptable metabolism. However, natural isolates are not always suitable for demanding biotechnological applications. Despite pseudomonads’ typically broad substrate range, their catabolism can be further enhanced through metabolic engineering, synthetic biology, and/or laboratory evolution to efficiently degrade, utilize, and valorize alternative waste substrates derived from lignocellulosic residues, synthetic plastics, C1 compounds, or their mixtures.
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