Immunohistochemical analysis of some ECM components in the nerve outgrowth regenerating through the knitted tubes.

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Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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SVÍŽENSKÁ Ivana DUBOVÝ Petr

Rok publikování 2000
Druh Článek ve sborníku
Konference Sborník lékařský
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Neurologie, neurochirurgie, neurovědy
Klíčová slova extracellular matrix; peripheral nerve; entubulation; regeneration
Popis The synthesis of the extracellular matrix (ECM) is an inevitable condition for the peripheral nerve regeneration. We investigated several components of the ECM (fibronectin, collagen IV, thrombospondin, chondroitin sulfate, and vitronectin) by the indirect immunohistochemical method in cryostat cross sections through nerve regenerates obtained from 6 adult female rats. The regenerate rejoined the proximal and distal stumps of the transected sciatic nerve that had been inserted into the guide prepared from the knitted vascular prosthesis. After 6 weeks from the transection, the regenerate consisted of a band of axons arranged in fascicles running along the longitudinal axis of the prosthesis. Our immunohistochemical results suggest that the ECM produced in the knitted vascular tube provides a milieu suitable for nerve regeneration.
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