Involvement of the 5-HT1A receptor subtype in regulation of anxiety-like and aggressive behaviour in mice
| Autoři | |
|---|---|
| Rok publikování | 2002 |
| Druh | Článek ve sborníku |
| Konference | Programme and abstracts of the Conference: NEUROSCIENCE IN THE THIRD MILLENIUM (X. International Congress of the Czech and Slovak Society) |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Farmakologie a lékárnická chemie |
| Klíčová slova | 5-HT1A receptor subtype; anxiety; aggression; agonistic behaviour; mice |
| Popis | Using the model of agonistic behviour in mice we evaluated the effect of the selective 5-HT1A receptor ligand S 15535 on paired social interactions of singly-housed male mice with non-aggressive group-housed partners. The study brought the evidence that S 15535 possesses marked antiaggressive effect and less pronounced anxiolytic activity, results resembling those of our earlier testing of other selective 5-HT1A ligands flesinoxane and buspirone. |
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