PREDICTIVE PARAMETERS OF THE WALDEYERS RING CARCINOMAS (A RETROSPECTIVE STUDY)

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Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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SMILEK Pavel KOSTŘICA Rom ROTTENBERG Jan VESELÝ Karel DUŠEK Ladislav

Rok publikování 2004
Druh Článek ve sborníku
Konference 5th European congress of Oto-Rhino-Laryngology head and Neck Surgery Abstract Book
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor ORL, oftalmologie, stomatologie
Klíčová slova head and neck cancer; predictiv parameters
Popis The analysis was carried out with a set of 60 patients suffering from carcinoma of the pharynx and supraglottis. Besides routine examinations, flow cytometric analysis of was performed, p53 and Ki-67 markers were established by means of immunohistochemistry. Furthermore mitotic and apoptotic index were established. Event-free survival (EFS) and overall survival (OS) were accepted as primary endpoints for the prognostic analyses. Cytokinetic parameters and proliferation activity were found as important predictors of the second level (after recognizing stage, grade and DNA status of the tumor). Multivariate combination of these markers contributed namely to the prognosis of early risk event (i.e. progression or relapse of the disease up to 12 months after the end of the therapy): ratio SPF/G2M cell fractions was found to be the key prognostic factor (p < 0.01). Early progressed cases have typically decreased SPF fraction combined with increased mitotic activity.
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