Depression, cortisol and somatoform dissociative symtoms

Varování

Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.

Název česky	Deprese, kortizol a somatoformní disociativní symptomy
Autoři	BOB Petr FREYBERGH PF JAŠOVÁ D. ŠUSTA M. PAVLAT J. ZIMA T. BENAKOVÁ H. BIZIK G. SVĚTLÁK Miroslav VEVERA J. MIKLOŠKO J. HÁJEK K. RABOCH J.
Rok publikování	2008
Druh	Článek v odborném periodiku
Časopis / Zdroj	NEUROENDOCRINOLOGY LETTERS
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Obor	Neurologie, neurochirurgie, neurovědy
Klíčová slova	Depression cortisol and somatoform dissociative symtoms
Popis	OBJECTIVE: According to recent findings neuroendocrine response related to dissociative symptoms is related to dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis but HPA axis functioning as related to dissociation is only partially understood. METHOD: With the aim to test the relationship between basal serum cortisol and dissociative symptoms measured as somatoform and psychic dissociation we performed clinical testing and biochemical analysis in 30 inpatients with diagnosis of unipolar depression (mean age 41.46, SD=13.68). RESULTS: The results show that cortisol as an index of HPA axis functioning manifests significant relationship to somatoform dissociative symptoms (r=-0.40; p=0.014). CONCLUSIONS: The result indicates relationship between HPA-axis reactivity and somatoform dissociative symptoms in unipolar depressive patients and suggests that somatoform dissociation presents a defense mechanism related to a passive coping response.
Související projekty:	Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS Centrum pro neuropsychiatrická studia traumatického stresu - NEURPSYCHTS