Occurrence of Chromosomal Abnormalities In Bone Marrow CD14+monocytes of Multiple Myeloma Patients

• Autoři: ŠVÁCHOVÁ Hana; GREŠLIKOVÁ Henrieta; MIKULÁŠOVÁ Aneta; BERÁNKOVÁ Kristina; NĚMEC Pavel; MAYER Jiří; HÁJEK Roman
• Rok publikování: 2010
• Druh: Konferenční abstrakty
• Fakulta / Pracoviště MU: Lékařská fakulta
• Popis: Increased bone marrow angiogenesis is a characteristic feature of multiple myeloma (MM). New blood vessels formation is provided by recruiting vascular endothelial cells from existing capillaries or circulating endothelial progenitor cells (EPC). EPCs have distinct monocytic features and can be cultured from CD14+ cells. In addition, monocytes were shown to contribute to angiogenesis as EPCs in vivo. It has been established that myeloid progenitor cells participate in the development of endothelial precursors. In MM, it has been reported that circulating EPCs carried the same chromosomal aberrations as neoplastic plasma cells (PC). It is possible that EPCs originate from common precursor that gives rise to both PCs and endothelial cells. The purpose of our pilot study was to clarify whether myeloid cells, CD14+ monocytes (CD14+MO), in MM might carry the same chromosomal abnormalities as CD138+PC.

Související projekty

• Univerzitní výzkumné centrum - Česká myelomová skupina (URC - CMG)
• Od klasických prognostických markerů ke klinicky aplikovatelným farmakogenomickým a farmakoproteomickým projektům u mnohočetného myelomu a monoklonálních gamapatií