ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI

Varování

Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	PAŘENICA Jiří PÁVKOVÁ GOLDBERGOVÁ Monika KALA Petr POLOCZEK Martin MAŇOUŠEK Jan PRYMUSOVÁ Krystyna KUBKOVÁ Lenka JARKOVSKÝ Jiří TOMČÍKOVÁ D. TOMAN Ondřej TESÁK Martin TOMANDL Josef VAŠKŮ Anna ŠPINAR Jindřich
Rok publikování	2010
Druh	Článek v odborném periodiku
Časopis / Zdroj	BMC Cardiovascular Disorders
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Obor	Genetika a molekulární biologie
Klíčová slova	ACE; polymorphism; gene; myocardial infarction
Popis	We evaluated the associations among angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism, ACE activity and post-myocardial infarction left ventricular dysfunction and acute heart failure early after presentation with MI with ST-segment elevation. A total of 556 patients with STEMI treated by primary PCI were the study population. The DD/ID genotypes were associated with a significantly higher risk of EF. These results suggest that the I/D polymorphism of ACE is associated with the development of LV dysfunction in the acute phase after STEMI. We demonstrated for the first time an association of the low ACE activity with the severe LV dysfunction, although patients with moderate LV dysfunction had higher level ACE activity than patients with preserved LV function.
Související projekty:	Komplexní managenent péče o pacienty s akutním srdečním selháním, jejich střednědobá prognóza a multivariantní prognostický model