Estimation of rate constants of drug binding to open channels of cardiac transient outward current

Varování

Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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ŠIMURDA Jiří ŠIMURDOVÁ Milena

Rok publikování 2012
Druh Článek v odborném periodiku
Časopis / Zdroj General Physiology and Biophysics
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.4149/gpb_2012_013
Obor Fyziologie
Klíčová slova Ito channel; Drug binding; Open state; Rate constants; Mathematical model
Popis An improved approach to the evaluation of the rate constants of drugs binding to the open channel underlying the transient outward potassium current Ito, is described. It is based on an analysis of a quantitative model formulated by a set of twelve differential equations. The rate constants are calculated from the time constants resulting from an approximation of the time course of apparent inactivation of the recorded Ito by two exponentials in the absence and by three exponentials in the presence, of a blocking agent. The model study confirmed significantly higher accuracy in comparison with the existing electrophysiological method.
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