ELECTROCHEMICAL STUDY OF SHORT CYTOSINE OLIGONUCLEOTIDES
| Autoři | |
|---|---|
| Rok publikování | 2012 |
| Druh | Článek ve sborníku |
| Konference | XII. Pracovní setkání fyzikálních chemiků a elektrochemiků |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Fyzikální chemie a teoretická chemie |
| Klíčová slova | cytosine;oligonucleotides;cyclic voltammetry;elimination voltammetry |
| Popis | Cytosine-rich oligodeoxynucleotides (C-rich ODNs) play diverse roles in the regulation of protein expression at both transcriptional and translational levels. A repetitive C sequence can be responsible for some diseases. It is commonly known that C-rich ODNs form the stable i-motif structure, interesting due to a crucial role in the process of genetic information transfer. The aim of this contribution is to find out the relationship between the structure of homo-ODNs in buffered solutions with the same ionic strength (I = 0.18 M) but with a different number of cytosines (dCx; x = 3, 4, 5, 6, 9). Using linear sweep voltammetry (LSV) and elimination voltammetry with linear scan (EVLS), electrochemical reduction signals studied on a mercury electrode reflect the conformation changes of the C-rich ODN chain. |
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