Diffusion Characteristics of Chlorine and Methoxy Derivatives of 6-benzylaminopurine Studied by Voltammetric Methods
| Autoři | |
|---|---|
| Rok publikování | 2012 |
| Druh | Článek ve sborníku |
| Konference | XXXII. Moderní elektrochemické metody. Sborník přednášek. |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Fyzikální chemie a teoretická chemie |
| Klíčová slova | chlorine and methoxy derivatives;diffusion coefficient;Delahay equation;linear sweep voltammetry;elimination voltammetry with linear scan |
| Popis | The metal complexes of chlorinated and methoxylated derivatives of 6 - benzylaminopurine (6-BAP) can be used as potential antineoplastic agents. From this point of view, the knowledge of the ability of these substances to diffuse into the intracellular area is very important. This property is characterized by the diffusion coefficient. The aim of our research is to determine the diffusion coefficients D of 6-BAP and its derivatives in buffered solutions (pH 3.21) containing 10% v/v CH3OH for two ionic strengths. Using the Delahay equation involving the reduction peaks of BAP derivatives on mercury electrode we calculated D and the charge transfer coefficient alpha we obtained from the elimination functions E1 and E4. The effect of some experimental parameters on D values was monitored. |
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