Comment on "Computational Model for Predicting Experimental RNA and DNA Nearest-Neighbor Free Energy Rankings"
| Autoři | |
|---|---|
| Rok publikování | 2012 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Journal of Physical Chemistry B |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://pubs.acs.org/doi/abs/10.1021/jp300659f?mi=0&af=R&pr... |
| Doi | http://dx.doi.org/10.1021/jp300659f |
| Obor | Biofyzika |
| Klíčová slova | ACID BASE-PAIRS; STACKING ENERGIES; STABILITY; PARAMETERS; STEPS |
| Přiložené soubory | |
| Popis | Recently, Johnson et al.1 reported interesting quantumchemical computations on base stacking and base pairing energies in B-DNA and A-RNA. They deduced that “there most definitely is a quantitative correlation between the quantum mechanical gas-phase stacking data and nucleic acid stability”. Such conclusion is, in our opinion, too optimistic and oversimplified. We identified several issues questioning the validity of this statement. |
| Související projekty: |