The Role of Oxidative Stress in Early Brain Injury after Subarachnoid Hemorrhage

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Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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JELÍNEK Matyáš JURAJDA Michal ĎURIŠ Kamil

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj Oxidative Medicine and Cellular Longevity
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.hindawi.com/journals/omcl/2020/8877116/
Doi http://dx.doi.org/10.1155/2020/8877116
Klíčová slova Oxidative Stress; Early Brain Injury; Subarachnoid Hemorrhage
Popis This review focuses on the problem of oxidative stress in early brain injury (EBI) after spontaneous subarachnoid hemorrhage (SAH). EBI involves complex pathophysiological mechanisms, including oxidative stress. In the first section, we describe the main sources of free radicals in EBI. There are several sources of excessive generation of free radicals from mitochondrial free radicals' generation and endoplasmic reticulum stress, to hemoglobin and enzymatic free radicals' generation. The second part focuses on the disruption of antioxidant mechanisms in EBI. The third section describes some newly found molecular mechanisms and pathway involved in oxidative stress after EBI. The last section is dedicated to the pathophysiological mechanisms through which free radicals mediate early brain injury.
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