The Role of Oxidative Stress in Early Brain Injury after Subarachnoid Hemorrhage

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Authors

JELÍNEK Matyáš JURAJDA Michal ĎURIŠ Kamil

Year of publication 2020
Type Article in Periodical
Magazine / Source Oxidative Medicine and Cellular Longevity
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.hindawi.com/journals/omcl/2020/8877116/
Doi http://dx.doi.org/10.1155/2020/8877116
Keywords Oxidative Stress; Early Brain Injury; Subarachnoid Hemorrhage
Description This review focuses on the problem of oxidative stress in early brain injury (EBI) after spontaneous subarachnoid hemorrhage (SAH). EBI involves complex pathophysiological mechanisms, including oxidative stress. In the first section, we describe the main sources of free radicals in EBI. There are several sources of excessive generation of free radicals from mitochondrial free radicals' generation and endoplasmic reticulum stress, to hemoglobin and enzymatic free radicals' generation. The second part focuses on the disruption of antioxidant mechanisms in EBI. The third section describes some newly found molecular mechanisms and pathway involved in oxidative stress after EBI. The last section is dedicated to the pathophysiological mechanisms through which free radicals mediate early brain injury.
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