Association of aneuploidy category with centrosome amplification in multiple myeloma
| Autoři | |
|---|---|
| Rok publikování | 2011 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Leukemia & Lymphoma |
| Fakulta / Pracoviště MU | |
| Citace | |
| Doi | http://dx.doi.org/10.3109/10428194.2011.587561 |
| Obor | Onkologie a hematologie |
| Klíčová slova | multiple myeloma; centrosome amplification; plasma cell; B-cell; hyperdiploid |
| Popis | Multiple myeloma is a lymphoproliferative disease characterized by clonal expansion of neoplastic plasma cells (PCs) within the bone marrow. Although PCs are recognized as fully malignant cells, the exact developmental stage at which malignant transformation occurs is still unknown. Since centrosome abnormalities constitute one of the most important mechanisms implicated in chromosomal instability in cancer, the aim of this study was to investigate a possible association of centrosome amplification in populations of B-cell lineage with specific chromosome aberrations and aneuploidy categories occurring in MM. For this purpose, a total of 140 patients with MM were included in the study. In our study, we showed a correlation between centrosome amplification in B cells and hyperdiploidy in plasma cells. This raises the suspicion of a possible impact of abnormal B cells in myeloma cell development. |
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