Association of aneuploidy category with centrosome amplification in multiple myeloma

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Authors

KRYUKOV Fedor DEMENTYEVA Elena Vladimirovna SMETANA Jan ŠEVČÍKOVÁ Sabina KUGLÍK Petr HÁJEK Roman

Year of publication 2011
Type Article in Periodical
Magazine / Source Leukemia & Lymphoma
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.3109/10428194.2011.587561
Field Oncology and hematology
Keywords multiple myeloma; centrosome amplification; plasma cell; B-cell; hyperdiploid
Description Multiple myeloma is a lymphoproliferative disease characterized by clonal expansion of neoplastic plasma cells (PCs) within the bone marrow. Although PCs are recognized as fully malignant cells, the exact developmental stage at which malignant transformation occurs is still unknown. Since centrosome abnormalities constitute one of the most important mechanisms implicated in chromosomal instability in cancer, the aim of this study was to investigate a possible association of centrosome amplification in populations of B-cell lineage with specific chromosome aberrations and aneuploidy categories occurring in MM. For this purpose, a total of 140 patients with MM were included in the study. In our study, we showed a correlation between centrosome amplification in B cells and hyperdiploidy in plasma cells. This raises the suspicion of a possible impact of abnormal B cells in myeloma cell development.
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