Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
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Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
- Spolupracující organizace
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Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 180
2023
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Characterisation of invisible conformation of domain 1.1 of σA factor of RNA polymerase from Bacillus subtilis
Rok: 2023, druh: Konferenční abstrakty
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Illuminating the mechanism and allosteric behavior of NanoLuc luciferase
Nature Communications, rok: 2023, ročník: 14, vydání: 1, DOI
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Insight into inherited anemia CDA-I: disease-associated mutations disrupt Codanin1-CDIN1 complex
Rok: 2023, druh: Další prezentace na konferencích
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Insight into peculiar adhesion of cells to plasma-chemically prepared multifunctional “amino-glue” surfaces
Plasma Processes and Polymers, rok: 2023, ročník: 20, vydání: 6, DOI
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Membrane-Targeting Perylenylethynylphenols Inactivate Medically Important Coronaviruses via the Singlet Oxygen Photogeneration Mechanism
Molecules, rok: 2023, ročník: 28, vydání: 17, DOI
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Nanoparticle tag counting for tissue imaging using single-particle ICP MS
Rok: 2023, druh: Konferenční abstrakty
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New insight into the biocompatibility/toxicity of graphene oxides and their reduced forms on Chlamydomonas reinhardtii
NANOIMPACT, rok: 2023, ročník: 31, vydání: July, DOI
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Proteogenomic Classification of Triple-Negative Breast Cancer for Prognosis and Targeted Therapy
Rok: 2023, druh: Konferenční abstrakty
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Proteotype classification of localized and metastatic renal cell carcinoma for prognosis and therapy response
Rok: 2023, druh: Konferenční abstrakty
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Proteotype classification of metastatic and localized renal cell carcinomas for prognosis and therapy response
Rok: 2023, druh: Konferenční abstrakty