Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
-
Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
- Cooperating Organization
-
Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 181
2024
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Computational Design of Pore-Forming Peptides with Potent Antimicrobial and Anticancer Activities
Journal of Medicinal Chemistry, year: 2024, volume: 67, edition: 16, DOI
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Merging Bambus[6]uril and Biotin[6]uril into an Enantiomerically Pure Monofunctionalized Hybrid Macrocycle
Organic Letters, year: 2024, volume: 26, edition: 1, DOI
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Structure and replication cycle of a virus infecting climate-modulating alga Emiliania huxleyi
Science advances, year: 2024, volume: 10, edition: 15, DOI
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Visible-Light-Activated Carbon Monoxide Release from Porphyrin-Flavonol Hybrids
Journal of the American Chemical Society, year: 2024, volume: 146, edition: 1, DOI
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W18O49 Nanowhiskers Decorating SiO2 Nanofibers: Lessons from In Situ SEM/TEM Growth to Large Scale Synthesis and Fundamental Structural Understanding
CRYSTAL GROWTH & DESIGN, year: 2024, volume: 24, edition: 1, DOI
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WS2 fullerene/plate nanofibers: The tunable crossroad between dimensionalities
Ceramics International, year: 2024, volume: 50, edition: 5, DOI
2023
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A combination of two resistance mechanisms is critical for tick-borne encephalitis virus escape from a broadly neutralizing human antibody
Cell Reports, year: 2023, volume: 42, edition: 9, DOI
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Advancing Enzyme's Stability and Catalytic Efficiency through Synergy of Force-Field Calculations, Evolutionary Analysis, and Machine Learning
ACS Catalysis, year: 2023, volume: 13, edition: 19, DOI
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Aerosol-assisted sol–gel synthesis of mesoporous Ag–Ta–SiO2 catalysts for the direct upgrading of ethanol to butadiene
RSC Sustainability, year: 2023, volume: 1, edition: 3, DOI
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Asymmetric Hydroxymethylation of Isoindolinones Using Bench-Stable Formaldehyde Surrogates
Year: 2023, type: Appeared in Conference without Proceedings