Project information
Konstrukce syntetické metabolické dráhy pro degradaci důležitého environmentlního polutantu proteinovým a metabolickým inženýrstvím

Information

This project doesn't include Faculty of Arts. It includes Faculty of Science. Official project website can be found on muni.cz.

Project Identification

GAP503/12/0572

Project Period

1/2012 - 12/2016

Investor / Pogramme / Project type

Czech Science Foundation

Standard Projects

MU Faculty or unit

Faculty of Science

Cílem tohoto projektu je sestavit syntetickou biochemickou dráhu klonováním genů enzymů optimalizovaných proteinovýmm inženýrstvím, vedoucí ke konstrukci bakterie degradující environmentální polutant 1,2,3-trichlorpropan (TCP). Tato bakterie bude růst na TCP jako jediném zdroji uhlíku a energie.

Publications

Total number of publications: 25

2014

Computational Tools for Designing and Engineering Enzymes.

DAMBORSKÝ Jiří BREZOVSKÝ Jan

Article in Periodical

Current Opinion in Chemical Biology, year: 2014, volume: 19, edition: april
Computer-Assisted Engineering of Synthetic Pathway for Biodegradation of Toxic Persistent Pollutant.

KURUMBANG Nagendra Prasad DVOŘÁK Pavel BENDL Jaroslav BREZOVSKÝ Jan PROKOP Zbyněk DAMBORSKÝ Jiří

Article in Periodical

ACS Synthetic Biology, year: 2014, volume: 3, edition: 3, DOI
Dynamics and Hydration Explain Failed Functional Transformation in Dehalogenase Design.

SYKORA J. BREZOVSKÝ Jan KOUDELÁKOVÁ Táňa LAHODA M. FOŘTOVÁ Andrea CHERNOVETS T. CHALOUPKOVÁ Radka ŠTĚPÁNKOVÁ Veronika PROKOP Zbyněk KUTA SMATANOVA I. HOF M. DAMBORSKÝ Jiří

Article in Periodical

Nature Chemical Biology, year: 2014, volume: 10, edition: 6
Fructose 1-Phosphate is the One and Only Physiological Effector of the Cra (FruR) regulator of Pseudomonas putida.

CHAVARRIA M. DURANTE-RODRIGUEZ G. KRELL T. SANTIAGO C. BREZOVSKÝ Jan DAMBORSKÝ Jiří DE LORENZO V.

Article in Periodical

FEBS Open Bio, year: 2014, volume: 4, edition: 2014, DOI
Immobilized Synthetic Pathway for Biodegradation of Toxic Recalcitrant Pollutant 1,2,3-Trichloropropane.

DVOŘÁK Pavel BIDMANOVÁ Šárka DAMBORSKÝ Jiří PROKOP Zbyněk

Article in Periodical

Environmental Science & Technology, year: 2014, volume: 48, edition: 12, DOI
Maximizing the Efficiency of Multi-enzyme Process by Stoichiometry Optimization.

DVOŘÁK Pavel KURUMBANG Nagendra Prasad BENDL Jaroslav BREZOVSKÝ Jan PROKOP Zbyněk DAMBORSKÝ Jiří

Article in Periodical

ChemBioChem, year: 2014, volume: 15, edition: 13, DOI
Stepwise Enhancement of Catalytic Performance of Haloalkane Dehalogenase LinB towards Beta-Hexachlorocyclohexane.

MORIUCHI Ryota TANAKA Hiroki NIKAWADORI Yuki ISHITSUKA Mayuko ITO Michihiro OHTSUBO Yoshiyuki TSUDA Masataka DAMBORSKÝ Jiří PROKOP Zbyněk NAGATA Yuji

Article in Periodical

Applied Microbiology and Biotechnology Express, year: 2014, volume: 4, edition: 72, DOI

2013

Expansion of Access Tunnels and Active-Site Cavities Influence Activity of Haloalkane Dehalogenases in Organic Cosolvents.

ŠTĚPÁNKOVÁ Veronika KHABIRI M. BREZOVSKÝ Jan PAVELKA Antonín SYKORA J. AMARO M. MINOFAR B. PROKOP Zbyněk HOF M. ETTRICH R. CHALOUPKOVÁ Radka DAMBORSKÝ Jiří

Article in Periodical

ChemBioChem, year: 2013, volume: 14, edition: 7, DOI
Gates of Enzymes.

GORA Artur Wiktor BREZOVSKÝ Jan DAMBORSKÝ Jiří

Article in Periodical

Chemical Reviews, year: 2013, volume: 113, edition: 8, DOI
Haloalkane dehalogenases: Biotechnological applications

KOUDELÁKOVÁ Táňa BIDMANOVÁ Šárka DVOŘÁK Pavel PAVELKA Antonín CHALOUPKOVÁ Radka PROKOP Zbyněk DAMBORSKÝ Jiří

Article in Periodical

Biotechnology Journal, year: 2013, volume: 8, edition: 1, DOI