Project information
Vývoj nových nízkomolekulárních protinádorových léčiv na principu syntetické letality
- Project Identification
- 15-33999A (kod CEP: NV15-33999A)
- Project Period
- 5/2015 - 12/2018
- Investor / Pogramme / Project type
-
Ministry of Health of the CR
- Ministry of Health Research Programme 2015 - 2022
- MU Faculty or unit
- Faculty of Medicine
- Cooperating Organization
-
Institute of Biophysics
- Responsible person doc. Mgr. Karel Souček, Ph.D.
- Responsible person prof. MUDr. Marek Svoboda, Ph.D.
zatím nemáme
Publications
Total number of publications: 17
2020
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ATR-CHK1 pathway as a therapeutic target for acute and chronic leukemias
CANCER TREATMENT REVIEWS, year: 2020, volume: 88, edition: AUG, DOI
2019
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ATR-CHK1 signaling is active and targetable in quiescent CLL cells
Year: 2019, type: Conference abstract
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Detection and functional analysis of TP53 mutations in CLL
Methods in Molecular Biology - Chronic Lymphocytic Leukemia: Methods and Protocols, year: 2019, number of pages: 20 s.
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Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells
Haematologica, year: 2019, volume: 104, edition: 12, DOI
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Potenciál inhibice proteinu checkpoint kinase 1 u chronické lymfocytární leukémie s mutacemi v genu TP53.
Year: 2019, type: Conference abstract
2018
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Biomonitoring práce s genotoxickými látkami a faktory v onkologickém zdravotnickém zařízení
Klinická onkologie, year: 2018, volume: 31, edition: Suppl1
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Hematological Findings in Non-Treated and gamma-Irradiated Mice Deficient for MIC-1/GDF15
Physiological research, year: 2018, volume: 67, edition: 4
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Inovativní inhibitor proteinu CHK1 indukuje apoptózu u buněk chronické lymfocytární leukémie s mutacemi v genu TP53
Year: 2018, type: Conference abstract
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Klinický význam sledování klonálního vývoje hematologické malignity
Transfuze a hematologie dnes, year: 2018
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Presence of growth/differentiation factor-15 cytokine in human follicular fluid, granulosa cells, and oocytes
Journal of Assisted Reproduction and Genetics, year: 2018, volume: 35, edition: 8, DOI