Project information
Genome-wide CRISPR/Cas9 screening to identify novel therapeutical targets for NOTCH1 and SF3B1 mutated B-cell chronic lymphocytic leukemia
- Project Identification
- MUNI/IGA/1516/2020
- Project Period
- 1/2021 - 12/2021
- Investor / Pogramme / Project type
-
Masaryk University
- Internal grant agency MU
- MU Faculty or unit
- Faculty of Medicine
B-cell chronic lymphocytic leukemia is a heterogeneous disease with a variety of somatic mutations found in patients, NOTCH1 and SF3B1 mutations being among the most frequent. They predict an adverse disease course and no targeted therapy for them exist. This project aims to perform CRISPR/Cas9 screen to reveal unique susceptibilities of NOTCH1 or SF3B1 mutated cells that might lead to the identification of novel therapeutical targets. These will be validated and molecular mechanisms proposed.
Publications
Total number of publications: 1
2022
-
Combined drug and CRISPR/CAS9 screening reveals specific targets for SF3B1- and NOTCH1- mutated CLL cells.
Year: 2022, type: Conference abstract