Project information
Genome-wide CRISPR/Cas9 screening to identify novel therapeutical targets for NOTCH1 and SF3B1 mutated B-cell chronic lymphocytic leukemia

Information

This project doesn't include Faculty of Arts. It includes Faculty of Medicine. Official project website can be found on muni.cz.
Project Identification
MUNI/IGA/1516/2020
Project Period
1/2021 - 12/2021
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Medicine

B-cell chronic lymphocytic leukemia is a heterogeneous disease with a variety of somatic mutations found in patients, NOTCH1 and SF3B1 mutations being among the most frequent. They predict an adverse disease course and no targeted therapy for them exist. This project aims to perform CRISPR/Cas9 screen to reveal unique susceptibilities of NOTCH1 or SF3B1 mutated cells that might lead to the identification of novel therapeutical targets. These will be validated and molecular mechanisms proposed.

Publications

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