Platelet-derived chemokines, PF-4 and RANTES, are significantly increased in hemodynamically significant degenerative aortic stenosis

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Authors

MOTOVSKA Z. ODVODYOVA D. KARPISEK M. HRABAKOVA H. KOCKA V. SIMKOVA I. KATINA Stanislav WIDIMSKY P.

Year of publication 2011
Type Article in Periodical
Magazine / Source International Journal of Cardiology
MU Faculty or unit

Faculty of Science

Citation
Web http://www.sciencedirect.com/science/article/pii/S0167527311008618
Doi http://dx.doi.org/10.1016/j.ijcard.2011.08.021
Field Applied statistics, operation research
Keywords Degenerative aortic stenosis; Platelet-derived chemokines; Platelet factor-4 (CXCL4); RANTES (CCL5)
Description Aortic valve stenosis (AoS) is the most common acquired valvular disorder found in developed countries, being present in 2% to 7% of adults over the age of 65 [1], [2] and [3]. Calcified AoS is a chronic progressive disease. The pathomechanisms leading to valve degeneration remain unknown. Valve disease shares many features with atherosclerosis. Platelet activation is an important constituent of the atherosclerotic process [4] and [5]. The study focused on two platelet-derived chemokines, which bridge three important components of atherogenesis: platelet activation, inflammation, and generation of atheroma. The study group was comprised of 124 consecutive patients being considered for aortic valve replacement for symptomatic degenerative trileaflet valvular AoS, and were undergoing cardiac catheterization in the Cardiocentre [6]. The exclusion criterion was the presence of an additional hemodynamically significant valve disease.
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